Structure activity Relationship

Engineering Novel Complement Activity into a Pulmonary Surfactant Protein

Complement activation / Biological Chemistry / Protein Engineering / Biological Sciences / Animals / Biological / Surface plasmon resonance / CHEMICAL SCIENCES / Rats / Substrate Specificity / Protein Conformation / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Pulmonary Surfactant / Molecular Sequence Data / Biological / Surface plasmon resonance / CHEMICAL SCIENCES / Rats / Substrate Specificity / Protein Conformation / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Pulmonary Surfactant / Molecular Sequence Data

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Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis

Immunology / Autoimmunity / Humans / Female / Male / Quantitative Structure Activity Relationship / Cosmetics / Molecular Mimicry / Occupational Exposure / Indexation / Structure activity Relationship / Primary Biliary Cirrhosis / Methyl Ester / Chemical Structure / Autoantibodies / Mitochondrial Proteins / Quantitative Structure Activity Relationship / Cosmetics / Molecular Mimicry / Occupational Exposure / Indexation / Structure activity Relationship / Primary Biliary Cirrhosis / Methyl Ester / Chemical Structure / Autoantibodies / Mitochondrial Proteins

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Mechanobiology of cartilage: how do internal and external stresses affect mechanochemical transduction and elastic energy storage

Mechanical Engineering / Biomedical Engineering / Locomotion / Extracellular Matrix / Osteoarthritis / Elasticity / Protein Structure and Function / Humans / Collagen / Animals / Energy Storage / Mechanical Stress / Articular Cartilage Wear / Energy Transfer / Structure activity Relationship / Weight Bearing / Articular Cartilage / Elasticity / Protein Structure and Function / Humans / Collagen / Animals / Energy Storage / Mechanical Stress / Articular Cartilage Wear / Energy Transfer / Structure activity Relationship / Weight Bearing / Articular Cartilage

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Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A 2

Calcium / Enzyme Inhibitors / Flavonoids / Animals / Male / Epidermis / Clinical Sciences / Guinea Pig / Quercetin / Structure activity Relationship / Biochemistry and cell biology / Apigenin / Epidermis / Clinical Sciences / Guinea Pig / Quercetin / Structure activity Relationship / Biochemistry and cell biology / Apigenin

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Guanidino Acids Act as ρ1 GABA C Receptor Antagonists

Biological Sciences / Humans / Circadian Rhythm / GABA receptors / Female / Animals / Nitrogen / Xenopus laevis / Taurine / Glycine / Guanidines / Oocytes / Structure activity Relationship / Voltage Clamp / Recombinant Proteins / Neurochemical / Animals / Nitrogen / Xenopus laevis / Taurine / Glycine / Guanidines / Oocytes / Structure activity Relationship / Voltage Clamp / Recombinant Proteins / Neurochemical

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Sesquiterpene Lactones with Potential Use as Natural Herbicide Models (I): trans,trans- Germacranolides

Engineering / Chemistry / Humans / Vegetables / Herbicides / Agricultural / Sesquiterpenes / CHEMICAL SCIENCES / Wild edible plants / Agricultural and Food Chemistry / Molecular Conformation / Structure activity Relationship / Lactones / Lycopersicon esculentum / Molecular Structure / Agricultural / Sesquiterpenes / CHEMICAL SCIENCES / Wild edible plants / Agricultural and Food Chemistry / Molecular Conformation / Structure activity Relationship / Lactones / Lycopersicon esculentum / Molecular Structure

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Dual Molecules as New Antimalarials

Animals / Plasmodium falciparum / Antimalarials / High School Chemistry / Biological activity / Structure activity Relationship / Choline / Pentamidine / Biochemistry and cell biology / Structure activity Relationship / Choline / Pentamidine / Biochemistry and cell biology

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The in vitro and in vivo enantioselectivity of etomidate implicates the GABA A receptor in general anaesthesia

Psychology / Neuropharmacology / Cell line / Evoked Potentials / Humans / Thalamus / Mice / Female / Animals / Male / Acetylcholine / Rat Brain / Synaptic Transmission / Rats / Radioligand Assay / Larva / Reflex / Xenopus laevis / Locomotor Activity / Oocytes / Structure activity Relationship / Neurosciences / GABA receptor / Glutamate Receptor / Etomidate / Thalamus / Mice / Female / Animals / Male / Acetylcholine / Rat Brain / Synaptic Transmission / Rats / Radioligand Assay / Larva / Reflex / Xenopus laevis / Locomotor Activity / Oocytes / Structure activity Relationship / Neurosciences / GABA receptor / Glutamate Receptor / Etomidate

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Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in Vitro

Bacteriology / Catalysis / Flow Cytometry / Virology / Calcium / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data

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Identification of amino acid residues critical for endonuclease and integration activities of HIV1 IN protein in Vitro

Bacteriology / Catalysis / Flow Cytometry / Virology / Calcium / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Biological / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data / Biological Chemistry / Magnetic Resonance Spectroscopy / Gene expression / Cell separation / Biocatalysis / Signal Transduction / HIV / Biological Sciences / Cell line / Identification / Humans / Mutagenesis / Sequence alignment / Mutation / Placenta / Virus / Escherichia coli / Animals / Biological / Plants / Monoclonal Antibodies / Chemotaxis / Phosphorylation / Plasmids / Affinity chromatography / Phenotype / Phosphotyrosine / CHEMICAL SCIENCES / Molecular cloning / Amino Acids / Mycoplasma Genitalium / Lysine / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Base Sequence / Amino Acid Substitution Rates / Chemokines / Structure activity Relationship / Newcastle Disease Virus / Recombinant Proteins / Protein Binding / Hydrolysis / DNA binding proteins / Site-directed Mutagenesis / Interleukin / Interferon Alpha / Down-Regulation / Molecular Sequence Data

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Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials

Organic Chemistry / Drug Discovery / Animals / Drug Resistance / Plasmodium falciparum / Antimalarials / Bioorganic and medicinal Chemistry / Structure activity Relationship / Antimalarials / Bioorganic and medicinal Chemistry / Structure activity Relationship

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P450 oxidoreductase deficiency

Genetics / Biology / Drug metabolism / STEROIDS / Multidisciplinary / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones

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P450 oxidoreductase deficiency

Genetics / Biology / Drug metabolism / STEROIDS / Multidisciplinary / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones / Humans / Mutation / Electron Transfer / Animals / Inborn errors of metabolism / Cytochrome C / Endocrine / Enzyme / Clinical Sciences / Deficiency / Genetic variation / Amino Acid Substitution Rates / Structure activity Relationship / Deficit / Knockout Mice / Syndrome / Bone and Bones

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In vivo active antimalarial isonitriles

Organic Chemistry / Porifera / Nitriles / Mice / Multidrug Resistance / Animals / Plasmodium falciparum / Antimalarials / Microbial Sensitivity Tests / Plasmodium yoelii / Structure activity Relationship / Animals / Plasmodium falciparum / Antimalarials / Microbial Sensitivity Tests / Plasmodium yoelii / Structure activity Relationship

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Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo

Organic Chemistry / Medicinal Chemistry / Calcium / Female / Animals / Male / Myocardial Infarction / Rabbits / Structure activity Relationship / Male / Myocardial Infarction / Rabbits / Structure activity Relationship

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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification

Organic Chemistry / Pharmacokinetics / In Vitro / Humans / Animals / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides

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